Endocrine Abstracts

Background: Chromogranin A (CgA) is the most abundant granin in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). As a tumor marker is moderately sensitive and nonspecific. Meningiomas are benign brain tumors that are usually to recur. Studies have shown in vitro and in vivo that meningiomas, regardless of histology and classification, express somatostatin receptors (SSTRs). GA68-DOTATATE PET is an exciting imaging modality that has shown significant a...

Lipodystrophic syndromes are a heterogeneous group of usually rare disorders, which have in common the selective and irreversible deficiency of adipose tissue in the absence of nutritional deprivation or catabolic state. Clinically, they are characterized by insulin resistance, related to a state of hypoleptinemia, with manifestations such as polycystic ovarian syndrome, type 2 diabetes mellitus, severe hypertriglyceridemia, and steatohepatitis among their most frequent metabo...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a rare condition (1–2% of causes for hypercalcemia) and may be confused with primary hyperparathyroidism. Diagnosis of FHH must be suspected in patients with a family history of chronic hypercalcemia, no symptoms and low urinary excretion. This disease is due to mutations in the calcium-sensing receptor (CASR) gene. Meningiomas are common intracranial tumors (15–20% of primary neoplasms of the central nervou...

A 50-year-old woman with no history of interest who was admitted in hospital for progressive headache 2 weeks of evolution refractory to treatment that was accompanied by emetic syndrome and paresthesias in face and arms. A CT scan of the skull (urgency) was performed which was normal. Neurology improves with analgesia and steroids, presenting mild drowsiness and mild hyponatremia (121 mEq/l). A cerebral MRI was performed, showing a right subacute hemorrhagic adenoma of 1 cm t...

Case 1: Thirty-eight year woman consulted to gynecologist for oligomenorrhea in the last 4 years; PRL 51 μg/l and TSH 8.4 mU/l were discovered, initiating treatment with levotiroxine (f-T4). She got pregnant, persisting elevated levels of TSH and increasing f-T4, with normal campimetry. With the diagnostic of hyperthyroidism due to inadequate TSH secretion, treatment with PTU was initiated. After normal delivery, MRI showed a 22 mm. hypophisary macroadenoma and a transesp...

This is a 38-year-old male, a regular user of a gym with the sole purpose of improving his physical performance and muscular strength and habitual consumer of hyperproteic dietary supplements. Among his PAs he denies toxic habits, and highlights the removal of the right testicle in childhood. Consultation for decreased desire and sexual potency, together with pain and turgor in the left breast; hair loss at the frontal level, in analytic carried out by the Primary Care Physici...

Thyroid hormone resistance (THR) is a rare dominantly inherited syndrome characterized by a reduced response of target tissues to thyroid hormone receptor. In most cases, THR is related to mutations in the thyroid hormone receptor beta gene (THRb). Management may be challenging in cases of gestation. Here we report the case of a pregnant patient with a possible not previously described mutation and negative genotype fetus.Case report: Thirty-two year old...

Introduction: In the geographical area of southern Spain, in the province of Huelva, we have detected prevalent cases of Dunnigan’s partial hereditary lipodystrophy. The genealogy, the suspicion phenotype and the coordination with the Genetics Service and Reference center, have borne fruit, and more and more families are detected in Our Area. The lipodystrophies, in general, are rare diseases that affect the adipose tissue, disappearance of it in different parts of the bo...

Introduction: First treatment in Graves’ disease consists in the administration of antithyroid drugs. The most common side effect is a rash, which affects about 5% patients and clears up if the drug is stopped. The other drug may then be used. The intolerance to both drugs is very rare, but in this situation early radioactive iodine or surgery may be the answer.Case report: Woman of 61 years old who developed primary hyperthiroidism, with levels of ...